3fnv

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[[Image:3fnv.png|left|200px]]
 
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{{STRUCTURE_3fnv| PDB=3fnv | SCENE= }}
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==Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2==
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<StructureSection load='3fnv' size='340' side='right'caption='[[3fnv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3fnv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FNV FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19580816}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fnv OCA], [https://pdbe.org/3fnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fnv RCSB], [https://www.ebi.ac.uk/pdbsum/3fnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fnv ProSAT]</span></td></tr>
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[[3fnv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FNV OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/CISD2_HUMAN CISD2_HUMAN] Defects in CISD2 are the cause of Wolfram syndrome type 2 (WFS2) [MIM:[https://omim.org/entry/604928 604928]. A rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. Other manifestations include diabetes insipidus, sensorineural deafness, dementia, psychiatric illnesses. WFS2 patients additionally show a strong bleeding tendency and gastrointestinal ulceration. Diabetes insipidus may be absent.<ref>PMID:17846994</ref>
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<ref group="xtra">PMID:019580816</ref><references group="xtra"/>
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== Function ==
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[https://www.uniprot.org/uniprot/CISD2_HUMAN CISD2_HUMAN] Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.<ref>PMID:17846994</ref> <ref>PMID:20010695</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/3fnv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fnv ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Abresch, E C.]]
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[[Category: Large Structures]]
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[[Category: Axelrod, H L.]]
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[[Category: Abresch EC]]
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[[Category: Cohen, A E.]]
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[[Category: Axelrod HL]]
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[[Category: Conlan, A R.]]
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[[Category: Cohen AE]]
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[[Category: Jennings, P A.]]
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[[Category: Conlan AR]]
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[[Category: Nechushtai, R.]]
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[[Category: Jennings PA]]
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[[Category: Paddock, M L.]]
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[[Category: Nechushtai R]]
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[[Category: Yee, D.]]
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[[Category: Paddock ML]]
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[[Category: Zuris, J.]]
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[[Category: Yee D]]
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[[Category: Cdgsh]]
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[[Category: Zuris J]]
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[[Category: Diabetes]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Iron]]
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[[Category: Iron-sulfur]]
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[[Category: Membrane]]
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[[Category: Membrane bound]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Oxidative stress]]
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[[Category: Thiazolidinedione]]
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[[Category: Transmembrane]]
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[[Category: Zinc-finger]]
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Current revision

Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2

PDB ID 3fnv

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