We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
3g80
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:3g80.png|left|200px]] | ||
| - | + | ==Nodamura virus protein b2, RNA-binding domain== | |
| + | <StructureSection load='3g80' size='340' side='right'caption='[[3g80]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3g80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nodamura_virus Nodamura virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G80 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g80 OCA], [https://pdbe.org/3g80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g80 RCSB], [https://www.ebi.ac.uk/pdbsum/3g80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g80 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B2_NODAM B2_NODAM] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.<ref>PMID:19249868</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Protein B2 from Nodamura virus (NMV B2), a member of the Nodavirus family, acts as a suppressor of RNA interference (RNAi). The N-terminal domain of NMV B2, consisting of residues 1-79, recognizes double-stranded RNA (dsRNA). The 2.5 A crystal structure of the RNA-binding domain of NMV B2 shows a dimeric, helical bundle structure. The structure shows a conserved set of RNA-binding residues compared with flock house virus B2, despite limited sequence identity. The crystal packing places the RNA-binding residues along one face of symmetry-related molecules, suggesting a potential platform for recognition of dsRNA. | ||
| - | + | Structure of the RNA-Binding Domain of Nodamura Virus Protein B2, a Suppressor of RNA Interference (dagger) , (double dagger).,Korber S, Shaik Syed Ali P, Chen JC Biochemistry. 2009 Mar 24;48(11):2307-9. PMID:19249868<ref>PMID:19249868</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 3g80" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | < | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
[[Category: Nodamura virus]] | [[Category: Nodamura virus]] | ||
| - | + | [[Category: Chen JC]] | |
| - | [[Category: Chen | + | [[Category: Korber S]] |
| - | [[Category: Korber | + | [[Category: Shaik Syed Ali P]] |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Nodamura virus protein b2, RNA-binding domain
| |||||||||||
