3fwe

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[[Image:3fwe.png|left|200px]]
 
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{{STRUCTURE_3fwe| PDB=3fwe | SCENE= }}
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==Crystal Structure of the Apo D138L CAP mutant==
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<StructureSection load='3fwe' size='340' side='right'caption='[[3fwe]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3fwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FWE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwe OCA], [https://pdbe.org/3fwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fwe RCSB], [https://www.ebi.ac.uk/pdbsum/3fwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fwe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/3fwe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fwe ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Apo D138L CAP mutant===
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==See Also==
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*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
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{{ABSTRACT_PUBMED_19805344}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3fwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWE OCA].
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:019805344</ref><references group="xtra"/>
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[[Category: Kong J]]
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[[Category: Escherichia coli k-12]]
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[[Category: Sharma H]]
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[[Category: Kong, J.]]
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[[Category: Steitz T]]
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[[Category: Sharma, H.]]
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[[Category: Wang J]]
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[[Category: Steitz, T.]]
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[[Category: Yu S]]
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[[Category: Wang, J.]]
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[[Category: Yu, S.]]
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[[Category: Activator]]
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[[Category: Allostery]]
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[[Category: Camp]]
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[[Category: Camp-binding]]
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[[Category: Dna-binding]]
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[[Category: Helix-turn-helix]]
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[[Category: Nucleotide-binding]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription regulator]]
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Current revision

Crystal Structure of the Apo D138L CAP mutant

PDB ID 3fwe

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