3fxv

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[[Image:3fxv.png|left|200px]]
 
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{{STRUCTURE_3fxv| PDB=3fxv | SCENE= }}
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==Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist==
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<StructureSection load='3fxv' size='340' side='right'caption='[[3fxv]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3fxv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FXV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=643:6-(4-{[3-(3,5-DICHLOROPYRIDIN-4-YL)-5-(1-METHYLETHYL)ISOXAZOL-4-YL]METHOXY}-2-METHYLPHENYL)-1-METHYL-1H-INDOLE-3-CARBOXYLIC+ACID'>643</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fxv OCA], [https://pdbe.org/3fxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fxv RCSB], [https://www.ebi.ac.uk/pdbsum/3fxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fxv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/3fxv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fxv ConSurf].
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<div style="clear:both"></div>
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===Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist===
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==See Also==
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*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
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{{ABSTRACT_PUBMED_19328688}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3fxv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXV OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019328688</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Benson, G M.]]
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[[Category: Large Structures]]
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[[Category: Bleicher, K.]]
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[[Category: Benson GM]]
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[[Category: Chen, L.]]
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[[Category: Bleicher K]]
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[[Category: Feng, S.]]
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[[Category: Chen L]]
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[[Category: Grether, U.]]
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[[Category: Feng S]]
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[[Category: He, Y.]]
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[[Category: Grether U]]
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[[Category: Hong, D.]]
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[[Category: He Y]]
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[[Category: Kuhn, B.]]
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[[Category: Hong D]]
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[[Category: Martin, R.]]
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[[Category: Kuhn B]]
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[[Category: Plancher, J M.]]
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[[Category: Martin R]]
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[[Category: Richter, H.]]
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[[Category: Plancher J-M]]
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[[Category: Rudolph, M G.]]
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[[Category: Richter H]]
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[[Category: Wang, Z.]]
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[[Category: Rudolph MG]]
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[[Category: Yang, M.]]
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[[Category: Wang Z]]
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[[Category: Zhang, Z.]]
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[[Category: Yang M]]
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[[Category: Activator]]
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[[Category: Zhang Z]]
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[[Category: Acyltransferase]]
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[[Category: Bile acid]]
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[[Category: Cholesterol]]
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[[Category: Dna-binding]]
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[[Category: Hormone receptor]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Proto-oncogene]]
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[[Category: Receptor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transferase]]
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[[Category: Zinc-finger]]
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Current revision

Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist

PDB ID 3fxv

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