4gee

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[[Image:4gee.png|left|200px]]
 
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{{STRUCTURE_4gee| PDB=4gee | SCENE= }}
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==Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.==
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<StructureSection load='4gee' size='340' side='right'caption='[[4gee]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gee]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GEE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WT:(1R,5S,6S)-3-[5-CHLORO-6-ETHYL-2-(PYRIMIDIN-5-YLOXY)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL]-3-AZABICYCLO[3.1.0]HEXAN-6-AMINE'>0WT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gee OCA], [https://pdbe.org/4gee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gee RCSB], [https://www.ebi.ac.uk/pdbsum/4gee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gee ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GYRB_ENTFA GYRB_ENTFA]
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===Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.===
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==See Also==
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*[[Gyrase 3D Structures|Gyrase 3D Structures]]
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{{ABSTRACT_PUBMED_23352267}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Enterococcus faecalis V583]]
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[[4gee]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis_v583 Enterococcus faecalis v583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEE OCA].
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[[Category: Large Structures]]
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[[Category: Enterococcus faecalis v583]]
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[[Category: Bensen DC]]
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[[Category: Bensen, D C.]]
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[[Category: Chen Z]]
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[[Category: Chen, Z.]]
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[[Category: Tari LW]]
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[[Category: Tari, L W.]]
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[[Category: Atp-binding]]
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[[Category: Atp-binding domain]]
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[[Category: Dna gyrase negatively supercoils closed circular double-stranded dna in an atp-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded dna ring]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Nucleotide-binding]]
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[[Category: Topoisomerase]]
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Current revision

Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

PDB ID 4gee

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