2ae5

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[[Image:2ae5.gif|left|200px]]<br /><applet load="2ae5" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2ae5, resolution 2.240&Aring;" />
 
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'''Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism'''<br />
 
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==About this Structure==
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==Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism==
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2AE5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_sp. Pseudomonas sp.] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Penicillin_amidase Penicillin amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.11 3.5.1.11] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AE5 OCA].
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<StructureSection load='2ae5' size='340' side='right'caption='[[2ae5]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
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[[Category: Penicillin amidase]]
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== Structural highlights ==
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[[Category: Protein complex]]
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<table><tr><td colspan='2'>[[2ae5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._GK16 Pseudomonas sp. GK16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AE5 FirstGlance]. <br>
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[[Category: Pseudomonas sp.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
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[[Category: Cho, K J.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Kim, J K.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ae5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ae5 OCA], [https://pdbe.org/2ae5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ae5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ae5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ae5 ProSAT]</span></td></tr>
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[[Category: Kim, K H.]]
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</table>
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[[Category: Kim, S H.]]
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== Function ==
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[[Category: Park, S S.]]
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[https://www.uniprot.org/uniprot/G7AC_PSEU7 G7AC_PSEU7] Catalyzes the deacylation of 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl-7-aminocephalosporanic acid or GL-7-ACA) to 7-aminocephalosporanic acid (7-ACA).<ref>PMID:2993240</ref>
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[[Category: Ryu, E K.]]
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== Evolutionary Conservation ==
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[[Category: Shin, H J.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Yang, I S.]]
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Check<jmol>
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[[Category: GOL]]
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<jmolCheckbox>
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[[Category: SO4]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/2ae5_consurf.spt"</scriptWhenChecked>
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[[Category: autoproteolysis]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: cephalosporin acylase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: intermediate structure]]
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</jmolCheckbox>
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[[Category: precursor activation]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ae5 ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:26:34 2008''
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==See Also==
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*[[Cephalosporin acylase 3D structures|Cephalosporin acylase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Pseudomonas sp. GK16]]
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[[Category: Cho KJ]]
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[[Category: Kim JK]]
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[[Category: Kim KH]]
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[[Category: Kim SH]]
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[[Category: Park SS]]
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[[Category: Ryu EK]]
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[[Category: Shin HJ]]
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[[Category: Yang IS]]

Current revision

Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism

PDB ID 2ae5

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