4fqn

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[[Image:4fqn.png|left|200px]]
 
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{{STRUCTURE_4fqn| PDB=4fqn | SCENE= }}
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==Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)==
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<StructureSection load='4fqn' size='340' side='right'caption='[[4fqn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fqn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQN FirstGlance]. <br>
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{{ABSTRACT_PUBMED_23266514}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqn OCA], [https://pdbe.org/4fqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqn RCSB], [https://www.ebi.ac.uk/pdbsum/4fqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqn ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[4fqn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQN OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN] Hereditary cerebral cavernous malformation. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boggon, T J.]]
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[[Category: Large Structures]]
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[[Category: Fisher, O S.]]
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[[Category: Boggon TJ]]
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[[Category: Li, X.]]
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[[Category: Fisher OS]]
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[[Category: Murphy, J W.]]
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[[Category: Li X]]
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[[Category: Zhang, R.]]
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[[Category: Murphy JW]]
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[[Category: Harmonin-homology domain]]
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[[Category: Zhang R]]
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[[Category: Helical domain]]
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[[Category: Homo-dimer]]
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[[Category: Protein binding]]
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[[Category: Protein-protein interaction]]
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Current revision

Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD)

PDB ID 4fqn

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