4hy1

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[[Image:4hy1.png|left|200px]]
 
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{{STRUCTURE_4hy1| PDB=4hy1 | SCENE= }}
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==Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.==
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<StructureSection load='4hy1' size='340' side='right'caption='[[4hy1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hy1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._holarctica_LVS Francisella tularensis subsp. holarctica LVS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HY1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19X:6-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1H-ISOINDOL-1-ONE'>19X</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hy1 OCA], [https://pdbe.org/4hy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hy1 RCSB], [https://www.ebi.ac.uk/pdbsum/4hy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hy1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARE_FRATH PARE_FRATH] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:23352267, PubMed:23294697, PubMed:24386374). Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00938]<ref>PMID:23352267</ref> <ref>PMID:24386374</ref> <ref>PMID:23294697</ref>
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===Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.===
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==See Also==
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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{{ABSTRACT_PUBMED_23352267}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4hy1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis_subsp._holarctica_lvs Francisella tularensis subsp. holarctica lvs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY1 OCA].
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</StructureSection>
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[[Category: Francisella tularensis subsp. holarctica lvs]]
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[[Category: Francisella tularensis subsp. holarctica LVS]]
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[[Category: Bensen, D C.]]
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[[Category: Large Structures]]
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[[Category: Creighton, C J.]]
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[[Category: Bensen DC]]
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[[Category: Kwan, B]]
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[[Category: Creighton CJ]]
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[[Category: Tari, L W.]]
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[[Category: Kwan B]]
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[[Category: Atp-binding]]
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[[Category: Tari LW]]
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[[Category: Atp-binding domain]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Nucleotide-binding]]
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[[Category: Topoisomerase]]
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Current revision

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

PDB ID 4hy1

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