3v6e
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:3v6e.png|left|200px]] | ||
| - | + | ==Crystal Structure of USP2 and a mutant form of Ubiquitin== | |
| + | <StructureSection load='3v6e' size='340' side='right'caption='[[3v6e]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3v6e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6E FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6e OCA], [https://pdbe.org/3v6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6e RCSB], [https://www.ebi.ac.uk/pdbsum/3v6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/UBP2_HUMAN UBP2_HUMAN] Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.<ref>PMID:17290220</ref> <ref>PMID:19917254</ref> <ref>PMID:19838211</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Thioesterase 3D structures|Thioesterase 3D structures]] | |
| - | + | *[[3D structures of ubiquitin|3D structures of ubiquitin]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Dhe-Paganon | + | [[Category: Dhe-Paganon S]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Ernst | + | [[Category: Ernst A]] |
| - | [[Category: Neculai | + | [[Category: Neculai M]] |
| - | + | [[Category: Sidhu S]] | |
| - | [[Category: Sidhu | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of USP2 and a mutant form of Ubiquitin
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Dhe-Paganon S | Edwards AM | Ernst A | Neculai M | Sidhu S | Weigelt J
