3w5q
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives== | |
| + | <StructureSection load='3w5q' size='340' side='right'caption='[[3w5q]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3w5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W5Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3KL:(5BETA,9BETA)-3-OXOCHOLAN-24-OIC+ACID'>3KL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w5q OCA], [https://pdbe.org/3w5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w5q RCSB], [https://www.ebi.ac.uk/pdbsum/3w5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w5q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Sandbox vdr|Sandbox vdr]] | |
| - | + | *[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Ikura T]] | ||
| + | [[Category: Ito N]] | ||
| + | [[Category: Masuno H]] | ||
Current revision
Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives
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