4ip9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of native human serum amyloid A1== | |
| - | + | <StructureSection load='4ip9' size='340' side='right'caption='[[4ip9]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ip9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IP9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ip9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ip9 OCA], [https://pdbe.org/4ip9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ip9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ip9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ip9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Major acute phase reactant. Apolipoprotein of the HDL complex. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lu J]] | ||
| + | [[Category: Sun PD]] | ||
Current revision
Structure of native human serum amyloid A1
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