4j8s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide== | |
| - | + | <StructureSection load='4j8s' size='340' side='right'caption='[[4j8s]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4j8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J8S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j8s OCA], [https://pdbe.org/4j8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j8s RCSB], [https://www.ebi.ac.uk/pdbsum/4j8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j8s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Blackshear PJ]] | ||
| + | [[Category: Fabian MR]] | ||
| + | [[Category: Frank F]] | ||
| + | [[Category: Karetnikov A]] | ||
| + | [[Category: Lai WS]] | ||
| + | [[Category: Nagar B]] | ||
| + | [[Category: Rouya C]] | ||
| + | [[Category: Siddiqui N]] | ||
| + | [[Category: Sonenberg N]] | ||
Current revision
Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide
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Categories: Homo sapiens | Large Structures | Blackshear PJ | Fabian MR | Frank F | Karetnikov A | Lai WS | Nagar B | Rouya C | Siddiqui N | Sonenberg N
