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4j8u
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4j8u is ON HOLD Authors: Adhireksan, Z., Davey, C.A. Description: X-ray structure of NCP145 with bound chlorido( 6-p-cymene)(N-phenyl-2-pyridinecar...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of NCP145 with chlorido(eta-6-p-cymene)(N-phenyl-2-pyridinecarbothioamide)osmium(II)== | |
| + | <StructureSection load='4j8u' size='340' side='right'caption='[[4j8u]], [[Resolution|resolution]] 2.38Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4j8u]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J8U FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ELJ:CHLORIDO(ETA-6-P-CYMENE)(N-PHENYL-2-PYRIDINECARBOTHIOAMIDE)OSMIUM(II)'>ELJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j8u OCA], [https://pdbe.org/4j8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j8u RCSB], [https://www.ebi.ac.uk/pdbsum/4j8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j8u ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
| - | + | ==See Also== | |
| - | + | *[[Histone 3D structures|Histone 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Adhireksan Z]] | ||
| + | [[Category: Davey CA]] | ||
Current revision
X-ray structure of NCP145 with chlorido(eta-6-p-cymene)(N-phenyl-2-pyridinecarbothioamide)osmium(II)
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