4jbk
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4jbk is ON HOLD Authors: Ru, H., Ni, X.-M., Crowley, C., Zhao, L.-X., Ding, W., Hung, L.-W., Shaw, N., Cheng, G.-H., Liu, Z.-J. Description: HINa d...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Molecular basis for abrogation of activation of pro-inflammatory cytokines== | |
| - | + | <StructureSection load='4jbk' size='340' side='right'caption='[[4jbk]], [[Resolution|resolution]] 2.96Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4jbk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.963Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbk OCA], [https://pdbe.org/4jbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbk RCSB], [https://www.ebi.ac.uk/pdbsum/4jbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Cheng G]] | ||
| + | [[Category: Crowley C]] | ||
| + | [[Category: Ding W]] | ||
| + | [[Category: Hung L-W]] | ||
| + | [[Category: Liu Z-J]] | ||
| + | [[Category: Ni X]] | ||
| + | [[Category: Ru H]] | ||
| + | [[Category: Shaw N]] | ||
| + | [[Category: Zhao L]] | ||
Current revision
Molecular basis for abrogation of activation of pro-inflammatory cytokines
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Categories: Large Structures | Mus musculus | Cheng G | Crowley C | Ding W | Hung L-W | Liu Z-J | Ni X | Ru H | Shaw N | Zhao L
