4jbk

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'''Unreleased structure'''
 
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The entry 4jbk is ON HOLD
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==Molecular basis for abrogation of activation of pro-inflammatory cytokines==
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<StructureSection load='4jbk' size='340' side='right'caption='[[4jbk]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
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Authors: Ru, H., Ni, X.-M., Crowley, C., Zhao, L.-X., Ding, W., Hung, L.-W., Shaw, N., Cheng, G.-H., Liu, Z.-J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jbk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBK FirstGlance]. <br>
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Description: HINa domain of p202a in complex with DNA
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.963&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbk OCA], [https://pdbe.org/4jbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbk RCSB], [https://www.ebi.ac.uk/pdbsum/4jbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Cheng G]]
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[[Category: Crowley C]]
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[[Category: Ding W]]
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[[Category: Hung L-W]]
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[[Category: Liu Z-J]]
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[[Category: Ni X]]
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[[Category: Ru H]]
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[[Category: Shaw N]]
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[[Category: Zhao L]]

Current revision

Molecular basis for abrogation of activation of pro-inflammatory cytokines

PDB ID 4jbk

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