4gsr

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[[Image:4gsr.jpg|left|200px]]
 
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{{STRUCTURE_4gsr| PDB=4gsr | SCENE= }}
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==Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains==
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<StructureSection load='4gsr' size='340' side='right'caption='[[4gsr]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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===Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gsr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EMT:2-(ETHYLMERCURI-THIO)-BENZOIC+ACID'>EMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[4gsr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSR OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsr OCA], [https://pdbe.org/4gsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsr RCSB], [https://www.ebi.ac.uk/pdbsum/4gsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LDT2_MYCTO LDT2_MYCTO] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is essential for virulence in a mouse model of acute infection.<ref>PMID:20305661</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: An, D R.]]
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[[Category: An DR]]
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[[Category: Han, B W.]]
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[[Category: Han BW]]
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[[Category: Im, H N.]]
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[[Category: Im HN]]
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[[Category: Kim, H S.]]
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[[Category: Kim HS]]
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[[Category: Kim, J.]]
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[[Category: Kim J]]
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[[Category: Kim, J Y.]]
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[[Category: Kim JY]]
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[[Category: Kim, S J.]]
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[[Category: Kim S-J]]
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[[Category: Lee, J Y.]]
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[[Category: Lee JY]]
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[[Category: Min, H K.]]
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[[Category: Min HK]]
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[[Category: Suh, S W.]]
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[[Category: Suh SW]]
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[[Category: Yoon, H J.]]
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[[Category: Yoon HJ]]
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[[Category: Yoon, J Y.]]
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[[Category: Yoon JY]]
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[[Category: D-transpeptidase]]
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[[Category: Transferase]]
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Current revision

Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

PDB ID 4gsr

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