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4ja0
From Proteopedia
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(New page: 200px {{STRUCTURE_4ja0| PDB=4ja0 | SCENE= }} ===Crystal structure of the invertebrate bi-functional purine biosynthesis enzyme PAICS at 2.8 A resolution=== ...) |
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| - | [[Image:4ja0.jpg|left|200px]] | ||
| - | + | ==Crystal structure of the invertebrate bi-functional purine biosynthesis enzyme PAICS at 2.8 A resolution== | |
| + | <StructureSection load='4ja0' size='340' side='right'caption='[[4ja0]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ja0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JA0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ja0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja0 OCA], [https://pdbe.org/4ja0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ja0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ja0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ja0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q1HQ66_BOMMO Q1HQ66_BOMMO] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Two important steps of the de novo purine biosynthesis pathway are catalyzed by the 5-aminoimidazole ribonucleotide carboxylase and the 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide synthetase enzymes. In most eukaryotic organisms, these two activities are present in the bifunctional enzyme complex known as PAICS. We have determined the 2.8-A resolution crystal structure of the 350-kDa invertebrate PAICS from insect cells (Trichoplusia ni) using single-wavelength anomalous dispersion methods. Comparison of insect PAICS to human and prokaryotic homologs provides insights into substrate binding and reveals a highly conserved enzymatic framework across divergent species. | ||
| - | + | Crystal structure of the invertebrate bifunctional purine biosynthesis enzyme PAICS at 2.8 A resolution.,Taschner M, Basquin J, Benda C, Lorentzen E Proteins. 2013 Aug;81(8):1473-8. doi: 10.1002/prot.24296. Epub 2013 Jun 1. PMID:23553965<ref>PMID:23553965</ref> | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4ja0" style="background-color:#fffaf0;"></div> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Phosphoribosylaminoimidazole carboxylase 3D structures|Phosphoribosylaminoimidazole carboxylase 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bombyx mori]] | [[Category: Bombyx mori]] | ||
| - | [[Category: Basquin | + | [[Category: Large Structures]] |
| - | [[Category: Benda | + | [[Category: Basquin J]] |
| - | [[Category: Lorentzen | + | [[Category: Benda C]] |
| - | [[Category: Taschner | + | [[Category: Lorentzen E]] |
| - | + | [[Category: Taschner M]] | |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the invertebrate bi-functional purine biosynthesis enzyme PAICS at 2.8 A resolution
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