2alf
From Proteopedia
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| - | [[Image:2alf.gif|left|200px]]<br /><applet load="2alf" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2alf, resolution 1.9Å" /> | ||
| - | '''crystal structure of human CypA mutant K131A'''<br /> | ||
| - | == | + | ==crystal structure of human CypA mutant K131A== |
| - | + | <StructureSection load='2alf' size='340' side='right'caption='[[2alf]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2alf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ALF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ALF FirstGlance]. <br> | |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2alf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2alf OCA], [https://pdbe.org/2alf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2alf RCSB], [https://www.ebi.ac.uk/pdbsum/2alf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2alf ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. | |
| - | [ | + | == Evolutionary Conservation == |
| - | [[ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/al/2alf_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2alf ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Cyclophilin 3D structures|Cyclophilin 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bi R-C]] | ||
| + | [[Category: Chen M-E]] | ||
| + | [[Category: Han Y]] | ||
| + | [[Category: Hu H]] | ||
| + | [[Category: Huang C-Q]] | ||
| + | [[Category: Liu H-L]] | ||
| + | [[Category: Yu L]] | ||
Current revision
crystal structure of human CypA mutant K131A
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Categories: Homo sapiens | Large Structures | Bi R-C | Chen M-E | Han Y | Hu H | Huang C-Q | Liu H-L | Yu L
