3h13

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3h13" [edit=sysop:move=sysop])
Current revision (09:57, 21 February 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3h13.png|left|200px]]
 
-
{{STRUCTURE_3h13| PDB=3h13 | SCENE= }}
+
==c-FLIPL protease-like domain==
-
 
+
<StructureSection load='3h13' size='340' side='right'caption='[[3h13]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
===c-FLIPL protease-like domain===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3h13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H13 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_19416807}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h13 OCA], [https://pdbe.org/3h13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h13 RCSB], [https://www.ebi.ac.uk/pdbsum/3h13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h13 ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[3h13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA].
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/CFLAR_HUMAN CFLAR_HUMAN] Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.<ref>PMID:9880531</ref>
-
==Reference==
+
== Evolutionary Conservation ==
-
<ref group="xtra">PMID:019416807</ref><references group="xtra"/>
+
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/3h13_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h13 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Jeffrey, P D.]]
+
[[Category: Large Structures]]
-
[[Category: Shi, Y.]]
+
[[Category: Jeffrey PD]]
-
[[Category: Yu, J W.]]
+
[[Category: Shi Y]]
-
[[Category: Apoptosis]]
+
[[Category: Yu JW]]
-
[[Category: Cell death]]
+
-
[[Category: Cflip-l]]
+
-
[[Category: Dimer]]
+
-
[[Category: Host-virus interaction]]
+

Current revision

c-FLIPL protease-like domain

PDB ID 3h13

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3h13"
Personal tools