3h6o

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[[Image:3h6o.png|left|200px]]
 
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{{STRUCTURE_3h6o| PDB=3h6o | SCENE= }}
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==Activator-Bound Structure of Human Pyruvate Kinase M2==
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<StructureSection load='3h6o' size='340' side='right'caption='[[3h6o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Activator-Bound Structure of Human Pyruvate Kinase M2===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3h6o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H6O FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D8G:6-(2-FLUOROBENZYL)-2,4-DIMETHYL-4,6-DIHYDRO-5H-THIENO[2,3 4,5]PYRROLO[2,3-D]PYRIDAZIN-5-ONE'>D8G</scene>, <scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[3h6o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H6O OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h6o OCA], [https://pdbe.org/3h6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h6o RCSB], [https://www.ebi.ac.uk/pdbsum/3h6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h6o ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/3h6o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h6o ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Pyruvate Kinase|Pyruvate Kinase]]
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*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pyruvate kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Auld, D.]]
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[[Category: Auld D]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Boxer, M.]]
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[[Category: Boxer M]]
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[[Category: Dimov, S.]]
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[[Category: Dimov S]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Hong, B.]]
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[[Category: Hong B]]
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[[Category: Inglese, J.]]
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[[Category: Inglese J]]
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[[Category: Jianq, J K.]]
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[[Category: Jianq J-K]]
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[[Category: Min, S.]]
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[[Category: Min S]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Skoumbourdis A]]
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[[Category: Skoumbourdis, A.]]
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[[Category: Southall N]]
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[[Category: Southall, N.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Thomas C]]
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[[Category: Thomas, C.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Activator]]
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[[Category: Allosteric enzyme]]
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[[Category: Glycolysis]]
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[[Category: Kinase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Pyruvate]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Activator-Bound Structure of Human Pyruvate Kinase M2

PDB ID 3h6o

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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