3h1k

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:14, 6 September 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3h1k.png|left|200px]]
 
-
{{STRUCTURE_3h1k| PDB=3h1k | SCENE= }}
+
==Chicken cytochrome BC1 complex with ZN++ and an iodinated derivative of kresoxim-methyl bound==
 +
<StructureSection load='3h1k' size='340' side='right'caption='[[3h1k]], [[Resolution|resolution]] 3.48&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3h1k]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H1K FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.48&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IKR:METHYL+(2E)-{2-[(4-IODO-2,5-DIMETHYLPHENOXY)METHYL]PHENYL}(METHOXYIMINO)ETHANOATE'>IKR</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>, <scene name='pdbligand=UQ:COENZYME+Q10,+(2Z,6E,10Z,14E,18E,22E,26Z)-ISOMER'>UQ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1k OCA], [https://pdbe.org/3h1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h1k RCSB], [https://www.ebi.ac.uk/pdbsum/3h1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h1k ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/D0VX31_CHICK D0VX31_CHICK]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/3h1k_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h1k ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The chicken mitochondrial ubiquinol cytochrome c oxidoreductase (bc(1) complex) is inhibited by Zn(2+) ions, but with higher K(i) ( approximately 3 microM) than the corresponding bovine enzyme. When equilibrated with mother liquor containing 200 microM ZnCl(2) for 7 days, the crystalline chicken bc(1) complex specifically binds Zn(2+) at 4 sites representing two sites on each monomer in the dimer. These two sites are close to the stigmatellin-binding site, taken to be center Q(o) of the Q-cycle mechanism, and are candidates for the inhibitory site. One binding site is actually in the hydrophobic channel between the Q(o) site and the bulk lipid phase, and may interfere with quinone binding. The other is in a hydrophilic area between cytochromes b and c(1), and might interfere with the egress of protons from the Q(o) site to the intermembrane aqueous medium. No zinc was bound near the putative proteolytic active site of subunits 1 and 2 (homologous to mitochondrial processing peptidase) under these conditions.
-
===Chicken cytochrome BC1 complex with ZN++ and an iodinated derivative of kresoxim-methyl bound===
+
Crystallographic location of two Zn(2+)-binding sites in the avian cytochrome bc(1) complex.,Berry EA, Zhang Z, Bellamy HD, Huang L Biochim Biophys Acta. 2000 Aug 15;1459(2-3):440-8. PMID:11004461<ref>PMID:11004461</ref>
-
{{ABSTRACT_PUBMED_11004461}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3h1k" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[3h1k]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1K OCA].
+
*[[Cytochrome bc1 3D structures|Cytochrome bc1 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:011004461</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
-
[[Category: Ubiquinol--cytochrome-c reductase]]
+
[[Category: Large Structures]]
-
[[Category: Bellamy, H D.]]
+
[[Category: Bellamy HD]]
-
[[Category: Berry, E A.]]
+
[[Category: Berry EA]]
-
[[Category: Huang, L S.]]
+
[[Category: Huang LS]]
-
[[Category: Zhang, Z.]]
+
[[Category: Zhang Z]]
-
[[Category: Complex iii]]
+
-
[[Category: Cytochrome b]]
+
-
[[Category: Cytochrome bc1]]
+
-
[[Category: Cytochrome c1]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Electron transport]]
+
-
[[Category: Heme]]
+
-
[[Category: Heme protein]]
+
-
[[Category: Inner membrane iron]]
+
-
[[Category: Iron]]
+
-
[[Category: Iron-sulfur]]
+
-
[[Category: Kresoxim-methyl]]
+
-
[[Category: Membrane]]
+
-
[[Category: Membrane protein]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Mitochondrion]]
+
-
[[Category: Mitochondrion inner membrane]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Redox enzyme]]
+
-
[[Category: Respiratory chain]]
+
-
[[Category: Rieske iron sulfur protein]]
+
-
[[Category: Transit peptide]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Transport]]
+
-
[[Category: Ubiquinone]]
+
-
[[Category: Zinc]]
+

Current revision

Chicken cytochrome BC1 complex with ZN++ and an iodinated derivative of kresoxim-methyl bound

PDB ID 3h1k

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3h1k"
Personal tools