3gs2

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[[Image:3gs2.png|left|200px]]
 
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{{STRUCTURE_3gs2| PDB=3gs2 | SCENE= }}
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==Ring1B C-terminal domain/Cbx7 Cbox Complex==
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<StructureSection load='3gs2' size='340' side='right'caption='[[3gs2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gs2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GS2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.699&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gs2 OCA], [https://pdbe.org/3gs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gs2 RCSB], [https://www.ebi.ac.uk/pdbsum/3gs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gs2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RING2_HUMAN RING2_HUMAN] E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity.<ref>PMID:11513855</ref> <ref>PMID:15386022</ref> <ref>PMID:16359901</ref> <ref>PMID:16714294</ref> <ref>PMID:20696397</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/3gs2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gs2 ConSurf].
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<div style="clear:both"></div>
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===Ring1B C-terminal domain/Cbx7 Cbox Complex===
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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{{ABSTRACT_PUBMED_20696397}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3gs2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GS2 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:020696397</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kim, C A.]]
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[[Category: Large Structures]]
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[[Category: Taylor, A B.]]
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[[Category: Kim CA]]
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[[Category: Wang, R.]]
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[[Category: Taylor AB]]
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[[Category: Cbox]]
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[[Category: Wang R]]
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[[Category: Cbx7]]
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[[Category: Chromatin regulator]]
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[[Category: Chromosomal protein]]
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[[Category: E3-ligase]]
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[[Category: Ligase]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polycomb]]
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[[Category: Repressor]]
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[[Category: Ring1b]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription repressor]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Zinc-finger]]
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Current revision

Ring1B C-terminal domain/Cbx7 Cbox Complex

PDB ID 3gs2

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