3gib

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[[Image:3gib.png|left|200px]]
 
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{{STRUCTURE_3gib| PDB=3gib | SCENE= }}
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==Crystal Structure of the Complex of the E. coli Hfq with Poly(A)==
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<StructureSection load='3gib' size='340' side='right'caption='[[3gib]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gib]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GIB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gib OCA], [https://pdbe.org/3gib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gib RCSB], [https://www.ebi.ac.uk/pdbsum/3gib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gib ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HFQ_ECOLI HFQ_ECOLI] RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32. Binds with high specificity to tRNAs. In vitro, stimulates synthesis of long tails by poly(A) polymerase I. Required for RNA phage Qbeta replication.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref> Seems to play a role in persister cell formation; upon overexpression decreases persister cell formation while deletion increases persister formation.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/3gib_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gib ConSurf].
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<div style="clear:both"></div>
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===Crystal Stucture of the Complex of the E. coli Hfq with Poly(A)===
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==See Also==
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*[[Protein Hfq 3D structures|Protein Hfq 3D structures]]
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{{ABSTRACT_PUBMED_19889981}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3gib]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GIB OCA].
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:019889981</ref><references group="xtra"/>
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[[Category: Brennan RG]]
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[[Category: Escherichia coli]]
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[[Category: Link TM]]
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[[Category: Brennan, R G.]]
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[[Category: Valentin-Hansen P]]
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[[Category: Link, T M.]]
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[[Category: Valentin-Hansen, P.]]
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[[Category: Degradosome component]]
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[[Category: Dna-binding]]
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[[Category: Hfq-rna complex]]
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[[Category: Rna binding protein]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Rna-binding]]
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[[Category: Stress response]]
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Current revision

Crystal Structure of the Complex of the E. coli Hfq with Poly(A)

PDB ID 3gib

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