4hw2

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[[Image:4hw2.png|left|200px]]
 
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{{STRUCTURE_4hw2| PDB=4hw2 | SCENE= }}
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==Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design==
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<StructureSection load='4hw2' size='340' side='right'caption='[[4hw2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hw2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HW2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19H:6-CHLORO-3-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1H-INDOLE-2-CARBOXYLIC+ACID'>19H</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hw2 OCA], [https://pdbe.org/4hw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hw2 RCSB], [https://www.ebi.ac.uk/pdbsum/4hw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hw2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
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===Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design===
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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{{ABSTRACT_PUBMED_23244564}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4hw2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HW2 OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Zhao, B.]]
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[[Category: Large Structures]]
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[[Category: Apoptosis]]
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[[Category: Zhao B]]
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[[Category: Apoptosis-inhibitor complex]]
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[[Category: Maintenance of viability]]
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[[Category: Regulation of apoptosis]]
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Current revision

Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design

PDB ID 4hw2

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