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4i1e
From Proteopedia
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| - | [[Image:4i1e.png|left|200px]] | ||
| - | + | ==Crystal structure of Rabbit Ryanodine Receptor 1 (residues 1-536) disease mutant G249R== | |
| + | <StructureSection load='4i1e' size='340' side='right'caption='[[4i1e]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4i1e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1E FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1e OCA], [https://pdbe.org/4i1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1e RCSB], [https://www.ebi.ac.uk/pdbsum/4i1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref> | ||
| - | === | + | ==See Also== |
| - | + | *[[Ryanodine receptor 3D structures|Ryanodine receptor 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | [[ | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
| - | [[Category: Kimlicka | + | [[Category: Kimlicka L]] |
| - | [[Category: Petegem | + | [[Category: Van Petegem F]] |
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| - | + | ||
Current revision
Crystal structure of Rabbit Ryanodine Receptor 1 (residues 1-536) disease mutant G249R
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