4jd3
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4jd3 is ON HOLD Authors: Gokulan, K., Sacchettini, J.C., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) Description: CCrystal Stru...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones== | |
| - | + | <StructureSection load='4jd3' size='340' side='right'caption='[[4jd3]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4jd3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JD3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jd3 OCA], [https://pdbe.org/4jd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jd3 RCSB], [https://www.ebi.ac.uk/pdbsum/4jd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jd3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PKS11_MYCTU PKS11_MYCTU] Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Gokulan K]] | ||
| + | [[Category: Sacchettini JC]] | ||
Current revision
Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
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