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2avp

From Proteopedia

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[[Image:2avp.gif|left|200px]]<br /><applet load="2avp" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2avp, resolution 2.040&Aring;" />
 
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'''Crystal structure of an 8 repeat consensus TPR superhelix'''<br />
 
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==Overview==
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==Crystal structure of an 8 repeat consensus TPR superhelix==
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The folding/unfolding transitions of a series of designed consensus tetratricopeptide repeat proteins are quantitatively described by the classical one-dimensional Ising model, which thus represents a new folding paradigm for repeat proteins. Moreover, for the first time for any protein, a theoretical model predicts the folding/unfolding transition midpoint and the width of the transition.
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<StructureSection load='2avp' size='340' side='right'caption='[[2avp]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2avp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AVP FirstGlance]. <br>
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2AVP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=CD:'>CD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AVP OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2avp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2avp OCA], [https://pdbe.org/2avp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2avp RCSB], [https://www.ebi.ac.uk/pdbsum/2avp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2avp ProSAT]</span></td></tr>
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A new folding paradigm for repeat proteins., Kajander T, Cortajarena AL, Main ER, Mochrie SG, Regan L, J Am Chem Soc. 2005 Jul 27;127(29):10188-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16028928 16028928]
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</table>
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[[Category: Protein complex]]
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== Evolutionary Conservation ==
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[[Category: Kajander, T.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Lopez-Cortajarena, A L.]]
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Check<jmol>
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[[Category: Main, E R.]]
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<jmolCheckbox>
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[[Category: Mochrie, S G.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/av/2avp_consurf.spt"</scriptWhenChecked>
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[[Category: Regan, L.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: CD]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: consensus protein]]
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</jmolCheckbox>
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[[Category: superhelix]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2avp ConSurf].
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[[Category: tetratricopeptide repeat]]
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<div style="clear:both"></div>
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[[Category: tpr]]
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__TOC__
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</StructureSection>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:31:28 2008''
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[[Category: Large Structures]]
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[[Category: Cortajarena AL]]
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[[Category: Kajander T]]
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[[Category: Main ER]]
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[[Category: Mochrie S]]
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[[Category: Regan L]]

Current revision

Crystal structure of an 8 repeat consensus TPR superhelix

PDB ID 2avp

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