This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3vrn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:34, 8 November 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3vrn.jpg|left|200px]]
 
-
{{STRUCTURE_3vrn| PDB=3vrn | SCENE= }}
+
==Crystal structure of the tyrosine kinase binding domain of Cbl-c==
 +
<StructureSection load='3vrn' size='340' side='right'caption='[[3vrn]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3vrn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VRN FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vrn OCA], [https://pdbe.org/3vrn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vrn RCSB], [https://www.ebi.ac.uk/pdbsum/3vrn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vrn ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CBLC_HUMAN CBLC_HUMAN] Regulator of EGFR mediated signal transduction.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Through their ubiquitin ligase activity, Cbl-family proteins suppress signalling mediated by protein-tyrosine kinases (PTKs), but can also function as adaptor proteins to positively regulate signalling. The tyrosine kinase binding (TKB) domain of this family is critical for binding with tyrosine-phosphorylated target proteins. Here, we analysed the crystal structure of the TKB domain of Cbl-c/Cbl-3 (Cbl-c TKB), which is a distinct member of the mammalian Cbl-family. In comparison with Cbl TKB, Cbl-c TKB showed restricted structural flexibility upon phosphopeptide binding. A mutation in Cbl-c TKB augmenting this flexibility enhanced its binding to target phosphoproteins. These results suggest that proteins, post-translational modifications or mutations that alter structural flexibility of the TKB domain of Cbl-family proteins could regulate their binding to target phosphoproteins and thereby, affect PTK-mediated signalling.
-
===Crystal structure of the tyrosine kinase binding domain of Cbl-c===
+
Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.,Takeshita K, Tezuka T, Isozaki Y, Yamashita E, Suzuki M, Kim M, Yamanashi Y, Yamamoto T, Nakagawa A J Biochem. 2012 Nov;152(5):487-95. doi: 10.1093/jb/mvs085. Epub 2012 Aug 9. PMID:22888118<ref>PMID:22888118</ref>
-
{{ABSTRACT_PUBMED_22888118}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 3vrn" style="background-color:#fffaf0;"></div>
-
[[3vrn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VRN OCA].
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Isozaki, Y.]]
+
[[Category: Large Structures]]
-
[[Category: Nakagawa, A.]]
+
[[Category: Isozaki Y]]
-
[[Category: Suzuki, M.]]
+
[[Category: Nakagawa A]]
-
[[Category: Takeshita, K.]]
+
[[Category: Suzuki M]]
-
[[Category: Tezuka, T.]]
+
[[Category: Takeshita K]]
-
[[Category: Yamamoto, T.]]
+
[[Category: Tezuka T]]
-
[[Category: Yamanashi, Y.]]
+
[[Category: Yamamoto T]]
-
[[Category: Yamashita, E.]]
+
[[Category: Yamanashi Y]]
-
[[Category: Calcium-binding ef hand]]
+
[[Category: Yamashita E]]
-
[[Category: Divergent sh2 domain]]
+
-
[[Category: Protein binding]]
+
-
[[Category: Ptb domain]]
+
-
[[Category: Regulator of egfr mediated signal transduction]]
+
-
[[Category: Ubiquitously expressed]]
+

Current revision

Crystal structure of the tyrosine kinase binding domain of Cbl-c

PDB ID 3vrn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3vrn"
Personal tools