3ht2

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[[Image:3ht2.png|left|200px]]
 
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{{STRUCTURE_3ht2| PDB=3ht2 | SCENE= }}
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==Zink containing polyketide cyclase RemF from Streptomyces resistomycificus==
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<StructureSection load='3ht2' size='340' side='right'caption='[[3ht2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ht2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_resistomycificus Streptomyces resistomycificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HT2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ht2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ht2 OCA], [https://pdbe.org/3ht2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ht2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ht2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ht2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q70DX5_9ACTN Q70DX5_9ACTN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/3ht2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ht2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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RemF is a polyketide cyclase involved in the biosynthesis of the aromatic pentacyclic metabolite resistomycin in Streptomyces resistomycificus. The enzyme is a member of a structurally hitherto uncharacterized class of polyketide cyclases. The crystal structure of RemF was determined by SAD and refined to 1.2 A resolution. The enzyme subunit shows a beta-sandwich structure with a topology characteristic for the cupin fold. RemF contains a metal binding site located at the bottom of the predominantly hydrophobic active site cavity. A zinc ion is coordinated to four histidine side chains, and two water molecules in octahedral ligand sphere geometry, highly unusual for zinc binding sites in proteins.
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===Zink containing polyketide cyclase RemF from Streptomyces resistomycificus===
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The polyketide cyclase RemF from Streptomyces resistomycificus contains an unusual octahedral zinc binding site.,Silvennoinen L, Sandalova T, Schneider G FEBS Lett. 2009 Sep 3;583(17):2917-21. Epub 2009 Aug 6. PMID:19665022<ref>PMID:19665022</ref>
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{{ABSTRACT_PUBMED_19665022}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3ht2" style="background-color:#fffaf0;"></div>
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[[3ht2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_resistomycificus Streptomyces resistomycificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HT2 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019665022</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces resistomycificus]]
[[Category: Streptomyces resistomycificus]]
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[[Category: Sandalova, T.]]
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[[Category: Sandalova T]]
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[[Category: Schneider, G.]]
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[[Category: Schneider G]]
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[[Category: Silvennoinen, L.]]
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[[Category: Silvennoinen L]]
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[[Category: Antibiotic biosynthesis]]
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[[Category: Cupin fold]]
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[[Category: Cyclase]]
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[[Category: Lyase]]
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[[Category: Metalloprotein]]
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[[Category: Resistomycin]]
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[[Category: Zn-binding]]
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Current revision

Zink containing polyketide cyclase RemF from Streptomyces resistomycificus

PDB ID 3ht2

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