2rrb

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[[Image:2rrb.png|left|200px]]
 
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{{STRUCTURE_2rrb| PDB=2rrb | SCENE= }}
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==Refinement of RNA binding domain in human Tra2 beta protein==
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<StructureSection load='2rrb' size='340' side='right'caption='[[2rrb]]' scene=''>
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===Refinement of RNA binding domain in human Tra2 beta protein===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rrb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRB FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20926394}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rrb OCA], [https://pdbe.org/2rrb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rrb RCSB], [https://www.ebi.ac.uk/pdbsum/2rrb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rrb ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2rrb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRB OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/TRA2B_HUMAN TRA2B_HUMAN] Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.<ref>PMID:9546399</ref> <ref>PMID:12165565</ref> <ref>PMID:12761049</ref> <ref>PMID:15009664</ref>
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==Reference==
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== References ==
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<ref group="xtra">PMID:020926394</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inoue, M.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Inoue M]]
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[[Category: Kuwasako, K.]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y.]]
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[[Category: Kuwasako K]]
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[[Category: Shirouzu, M.]]
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[[Category: Muto Y]]
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[[Category: Someya, T.]]
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[[Category: Shirouzu M]]
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[[Category: Sugano, S.]]
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[[Category: Someya T]]
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[[Category: Takahashi, M.]]
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[[Category: Sugano S]]
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[[Category: Terada, T.]]
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[[Category: Takahashi M]]
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[[Category: Tsuda, K.]]
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[[Category: Terada T]]
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[[Category: Yokoyama, S.]]
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[[Category: Tsuda K]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Yokoyama S]]
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[[Category: Nppsfa]]
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[[Category: Rbd]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rna binding protein]]
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[[Category: Rrm domain]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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Current revision

Refinement of RNA binding domain in human Tra2 beta protein

PDB ID 2rrb

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