2b02

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[[Image:2b02.jpg|left|200px]]<br /><applet load="2b02" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2b02, resolution 1.50&Aring;" />
 
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'''Crystal Structure of ARNT PAS-B Domain'''<br />
 
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==Disease==
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==Crystal Structure of ARNT PAS-B Domain==
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Known disease associated with this structure: Leukemia, acute myeloblastic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=126110 126110]]
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<StructureSection load='2b02' size='340' side='right'caption='[[2b02]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B02 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b02 OCA], [https://pdbe.org/2b02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b02 RCSB], [https://www.ebi.ac.uk/pdbsum/2b02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b02 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARNT_HUMAN ARNT_HUMAN] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/2b02_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b02 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2B02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B02 OCA].
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*[[Factor inhibiting HIF|Factor inhibiting HIF]]
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*[[3D structures of hypoxia-inducible factor|3D structures of hypoxia-inducible factor]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Botuyan, M V.]]
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[[Category: Botuyan MV]]
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[[Category: Lee, J.]]
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[[Category: Lee J]]
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[[Category: Mer, G.]]
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[[Category: Mer G]]
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[[Category: Nomine, Y.]]
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[[Category: Nomine Y]]
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[[Category: Ohh, M.]]
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[[Category: Ohh M]]
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[[Category: Thompson, J R.]]
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[[Category: Thompson JR]]
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[[Category: ahr]]
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[[Category: arnt]]
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[[Category: hif]]
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[[Category: pas domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:32:48 2008''
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Current revision

Crystal Structure of ARNT PAS-B Domain

PDB ID 2b02

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