Anti-silencing factor

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<StructureSection load='1roc' size='400' side='right' caption='Structure of yeast anti-silencing factor complex with Br- (PDB entry [[1roc]])' scene=''>
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<StructureSection load='1roc' size='350' side='right' caption='Structure of yeast anti-silencing factor complex with Br- ions (PDB entry [[1roc]])' scene='51/516489/Cv/1'>
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__TOC__
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== Function ==
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'''Anti-silencing factor''' (ASF) or histone chaperone assits in chromatin assembly and remodeling during replication, transcription activation and gene silencing. ASF cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with histone regulatory homolog A (HIRA) to promote replication-independent assembly.
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'''Anti-silencing factor''' (ASF) or '''histone chaperone''' assits in chromatin assembly and remodeling during replication, transcription activation and gene silencing. ASF cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with histone regulatory homolog A (HIRA) to promote replication-independent assembly.<ref>PMID:16980972</ref>
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==3D structures of anti-silencing factor==
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== Structural highlights ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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ASF has an 80 residue segment which binds RNA at the N-terminal and a C-terminal which is composed of 80% Ser and Arg.
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[[1roc]], [[1wg3]] – yASF – yeast<br />
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[[2idc]] – yASF/H3<br />
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[[1tey]] – hASF N terminal – human - NMR<br />
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[[2io5]] – hASF + histone H3.1 + histone H4<br />
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[[2hue]] - yASF + histone H3 + histone H4<br />
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[[4eo5]] - yASF + histone H3.2 (mutant) + histone H4 (mutant) <br />
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[[2z3f]] – yASF + SPCIA1<br />
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[[2i32]] – hASF + HIRA<br />
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[[2z34]] – hASF N terminal + HIR1<br />
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[[3aad]] – hASF + transcription initiation factor TFIID<br />
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[[2ygv]] – yASF + serine/threonine protein kinase RAD53
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==3D structures of anti-silencing factor==
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[[Anti-silencing factor 3D structures]]
</StructureSection>
</StructureSection>
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==References==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of yeast anti-silencing factor complex with Br- ions (PDB entry 1roc)

Drag the structure with the mouse to rotate

References

  1. ↑ Tang Y, Poustovoitov MV, Zhao K, Garfinkel M, Canutescu A, Dunbrack R, Adams PD, Marmorstein R. Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. Nat Struct Mol Biol. 2006 Oct;13(10):921-9. Epub 2006 Sep 17. PMID:16980972 doi:10.1038/nsmb1147

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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