Ceruloplasmin
From Proteopedia
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| - | + | <StructureSection load='1kcw' size='350' side='right' caption='Glycosylated human ceruloplasmin complex with Cu+2 ions (orange) and O atoms (red) (PDB entry [[1kcw]])' scene='46/467272/Cv/2'> | |
| + | __TOC__ | ||
| + | == Function == | ||
| - | '''Ceruloplasmin''' (CP) is a ferroxidase which is the major copper-carrying protein in the blood. It functions in iron metabolism. | + | '''Ceruloplasmin''' (CP) is a ferroxidase which is the major copper-carrying protein in the blood. It functions in iron metabolism.<ref>PMID:12055353</ref> |
| - | + | == Relevance == | |
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| + | CP testing is used in diagnosis of the rare inherited disorder - Wilson disease. | ||
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| + | == Disease == | ||
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| + | CP mutation causes the autosomal recessive disorder - Aceruloplasminemia which results in accumulation of iron in the brain. | ||
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| + | == Structural highlights == | ||
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| + | <scene name='46/467272/Cv/8'>Cu-O-Cu coordination site</scene> and | ||
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| + | <scene name='46/467272/Cv/9'>Cu-O coordination site</scene> in human ceruloplasmin (PDB entry [[1kcw]]). | ||
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| + | </StructureSection> | ||
==3D structures of ceruloplasmin== | ==3D structures of ceruloplasmin== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[1kcw]], [[2j5w]] – hCP - human | + | [[1kcw]], [[2j5w]], [[4enz]] – hCP - human<br /> |
| + | [[4ejx]] – hCP + myeloperoxidase<br /> | ||
| + | [[5n0k]], [[5n4l]] – CP – rat<br /> | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of ceruloplasmin
Updated on 11-February-2019
1kcw, 2j5w, 4enz – hCP - human
4ejx – hCP + myeloperoxidase
5n0k, 5n4l – CP – rat
References
- ↑ Hellman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annu Rev Nutr. 2002;22:439-58. Epub 2002 Apr 4. PMID:12055353 doi:http://dx.doi.org/10.1146/annurev.nutr.22.012502.114457
