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| - | [[Image:2b2r.gif|left|200px]]<br /><applet load="2b2r" size="350" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[5sw6]] This PDB entry is obsolete and replaced by 5sw6 |
| - | caption="2b2r, resolution 1.90Å" />
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| - | '''Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH5.6'''<br />
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| - | ==Overview==
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| - | The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp.
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| - | ==About this Structure==
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| - | 2B2R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=O:'>O</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2R OCA].
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| - | ==Reference==
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| - | A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16211084 16211084]
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| - | [[Category: Burkholderia pseudomallei]]
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| - | [[Category: Catalase]]
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| - | [[Category: Single protein]]
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| - | [[Category: Carpena, X.]]
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| - | [[Category: Deemagarn, T.]]
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| - | [[Category: Fita, I.]]
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| - | [[Category: Ivancich, A.]]
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| - | [[Category: Loewen, P C.]]
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| - | [[Category: Singh, R.]]
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| - | [[Category: Switala, J.]]
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| - | [[Category: Wiseman, B.]]
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| - | [[Category: HEM]]
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| - | [[Category: NA]]
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| - | [[Category: O]]
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| - | [[Category: catalase-peroxidase]]
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| - | [[Category: compound i]]
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| - | [[Category: katg]]
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| - | [[Category: oxoferryl species]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:33:31 2008''
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