2l3j
From Proteopedia
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| - | {{Large structure}} | ||
| - | {{STRUCTURE_2l3j| PDB=2l3j | SCENE= }} | ||
| - | ===The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific read out of the minor groove=== | ||
| - | {{ABSTRACT_PUBMED_20946981}} | ||
| - | == | + | ==The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific read out of the minor groove== |
| - | [[2l3j]] is a 2 chain structure with sequence from [ | + | <StructureSection load='2l3j' size='340' side='right'caption='[[2l3j]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2l3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3J FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3j OCA], [https://pdbe.org/2l3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3j RCSB], [https://www.ebi.ac.uk/pdbsum/2l3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3j ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RED1_RAT RED1_RAT] Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently (By similarity). Can inhibit cell proliferation and migration and can stimulate exocytosis.<ref>PMID:20501795</ref> <ref>PMID:16472753</ref> <ref>PMID:20946981</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Adenosine deaminase 3D structures|Adenosine deaminase 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Allain | + | [[Category: Allain FH-T]] |
| - | [[Category: Oberstrass | + | [[Category: Oberstrass FC]] |
| - | [[Category: Stefl | + | [[Category: Stefl R]] |
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Current revision
The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific read out of the minor groove
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