3utm
From Proteopedia
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| - | {{STRUCTURE_3utm| PDB=3utm | SCENE= }} | ||
| - | ===Crystal structure of a mouse Tankyrase-Axin complex=== | ||
| - | {{ABSTRACT_PUBMED_22307604}} | ||
| - | == | + | ==Crystal structure of a mouse Tankyrase-Axin complex== |
| - | [[3utm]] is a 3 chain structure with sequence from [ | + | <StructureSection load='3utm' size='340' side='right'caption='[[3utm]], [[Resolution|resolution]] 2.00Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3utm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UTM FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3utm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3utm OCA], [https://pdbe.org/3utm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3utm RCSB], [https://www.ebi.ac.uk/pdbsum/3utm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3utm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TNKS1_MOUSE TNKS1_MOUSE] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1 (By similarity). | ||
==See Also== | ==See Also== | ||
| - | *[[Axin|Axin]] | + | *[[Axin 3D structures|Axin 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | < | + | [[Category: Large Structures]] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Cheng | + | [[Category: Cheng Z]] |
| - | [[Category: Morrone | + | [[Category: Morrone S]] |
| - | [[Category: Xu | + | [[Category: Xu W]] |
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Current revision
Crystal structure of a mouse Tankyrase-Axin complex
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