1ju4
From Proteopedia
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| - | {{STRUCTURE_1ju4| PDB=1ju4 | SCENE= }} | ||
| - | ===BACTERIAL COCAINE ESTERASE COMPLEX WITH PRODUCT=== | ||
| - | {{ABSTRACT_PUBMED_11742345}} | ||
| - | == | + | ==BACTERIAL COCAINE ESTERASE COMPLEX WITH PRODUCT== |
| - | [[1ju4]] is a 1 chain structure with sequence from [ | + | <StructureSection load='1ju4' size='340' side='right'caption='[[1ju4]], [[Resolution|resolution]] 1.63Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1ju4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._MB1 Rhodococcus sp. MB1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JU4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ju4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ju4 OCA], [https://pdbe.org/1ju4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ju4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ju4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ju4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/COCE_RHOSM COCE_RHOSM] Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.<ref>PMID:10698749</ref> <ref>PMID:16968810</ref> <ref>PMID:12369817</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1ju4_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ju4 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Cocaine esterase|Cocaine esterase]] | *[[Cocaine esterase|Cocaine esterase]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: Rhodococcus sp. | + | </StructureSection> |
| - | [[Category: Basran | + | [[Category: Large Structures]] |
| - | [[Category: Bruce | + | [[Category: Rhodococcus sp. MB1]] |
| - | [[Category: Larsen | + | [[Category: Basran A]] |
| - | [[Category: Lerner | + | [[Category: Bruce NC]] |
| - | [[Category: Rosser | + | [[Category: Larsen NA]] |
| - | [[Category: Stevens | + | [[Category: Lerner RA]] |
| - | [[Category: Turner | + | [[Category: Rosser SJ]] |
| - | [[Category: Wilson | + | [[Category: Stevens J]] |
| - | + | [[Category: Turner JM]] | |
| - | + | [[Category: Wilson IA]] | |
Current revision
BACTERIAL COCAINE ESTERASE COMPLEX WITH PRODUCT
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Categories: Large Structures | Rhodococcus sp. MB1 | Basran A | Bruce NC | Larsen NA | Lerner RA | Rosser SJ | Stevens J | Turner JM | Wilson IA
