3k5b

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{{STRUCTURE_3k5b| PDB=3k5b | SCENE= }}
 
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===Crystal structure of the peripheral stalk of Thermus thermophilus H+-ATPase/synthase===
 
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{{ABSTRACT_PUBMED_20173764}}
 
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==About this Structure==
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==Crystal structure of the peripheral stalk of Thermus thermophilus H+-ATPase/synthase==
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[[3k5b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K5B OCA].
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<StructureSection load='3k5b' size='340' side='right'caption='[[3k5b]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3k5b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K5B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k5b OCA], [https://pdbe.org/3k5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k5b RCSB], [https://www.ebi.ac.uk/pdbsum/3k5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k5b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5SIT5_THET8 Q5SIT5_THET8]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/3k5b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k5b ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Proton-translocating ATPases are ubiquitous protein complexes that couple ATP catalysis with proton translocation via a rotary catalytic mechanism. The peripheral stalks are essential components that counteract torque generated from proton translocation during ATP synthesis or from ATP hydrolysis during proton pumping. Despite their essential role, the peripheral stalks are the least conserved component of the complexes, differing substantially between subtypes in composition and stoichiometry. We have determined the crystal structure of the peripheral stalk of the A-type ATPase/synthase from Thermus thermophilus consisting of subunits E and G. The structure contains a heterodimeric right-handed coiled coil, a protein fold never observed before. We have fitted this structure into the 23 A resolution EM density of the intact A-ATPase complex, revealing the precise location of the peripheral stalk and new implications for the function and assembly of proton-translocating ATPases.
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==See Also==
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The structure of the peripheral stalk of Thermus thermophilus H+-ATPase/synthase.,Lee LK, Stewart AG, Donohoe M, Bernal RA, Stock D Nat Struct Mol Biol. 2010 Mar;17(3):373-8. Epub 2010 Feb 21. PMID:20173764<ref>PMID:20173764</ref>
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*[[ATP synthase|ATP synthase]]
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*[[V-ATPase|V-ATPase]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020173764</ref><references group="xtra"/>
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</div>
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[[Category: Thermus thermophilus]]
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<div class="pdbe-citations 3k5b" style="background-color:#fffaf0;"></div>
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[[Category: Bernal, R A.]]
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[[Category: Donohoe, M.]]
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==See Also==
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[[Category: Lee, L K.]]
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*[[ATPase 3D structures|ATPase 3D structures]]
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[[Category: Stewart, A G.]]
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== References ==
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[[Category: Stock, D.]]
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<references/>
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[[Category: A-type atpase/synthase]]
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__TOC__
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[[Category: Atp synthesis]]
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</StructureSection>
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[[Category: Hydrogen ion transport]]
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[[Category: Large Structures]]
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[[Category: Hydrolase]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Ion transport]]
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[[Category: Bernal RA]]
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[[Category: Peripheral stalk]]
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[[Category: Donohoe M]]
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[[Category: Peripheral stator]]
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[[Category: Lee LK]]
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[[Category: Right handed coiled coil]]
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[[Category: Stewart AG]]
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[[Category: Transport]]
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[[Category: Stock D]]
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[[Category: V-type atpase/synthase]]
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[[Category: Vacuolar atpase/synthase]]
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Current revision

Crystal structure of the peripheral stalk of Thermus thermophilus H+-ATPase/synthase

PDB ID 3k5b

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