3gd8

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{{STRUCTURE_3gd8| PDB=3gd8 | SCENE= }}
 
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===Crystal Structure of Human Aquaporin 4 at 1.8 and its Mechanism of Conductance===
 
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{{ABSTRACT_PUBMED_19383790}}
 
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==About this Structure==
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==Crystal Structure of Human Aquaporin 4 at 1.8 and its Mechanism of Conductance==
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[[3gd8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GD8 OCA].
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<StructureSection load='3gd8' size='340' side='right'caption='[[3gd8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gd8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GD8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gd8 OCA], [https://pdbe.org/3gd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gd8 RCSB], [https://www.ebi.ac.uk/pdbsum/3gd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gd8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AQP4_HUMAN AQP4_HUMAN] Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gd/3gd8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gd8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aquaporin|Aquaporin]]
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*[[Aquaporin 3D structures|Aquaporin 3D structures]]
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*[[Aquaporin 4|Aquaporin 4]]
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019383790</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: CSMP, Center for Structures of Membrane Proteins.]]
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[[Category: Large Structures]]
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[[Category: Chorny, I.]]
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[[Category: Chorny I]]
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[[Category: Harries, W E.C.]]
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[[Category: Harries WEC]]
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[[Category: Ho, J D.]]
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[[Category: Ho JD]]
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[[Category: Miercke, L J.W.]]
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[[Category: Miercke LJW]]
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[[Category: Robbins, R A.]]
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[[Category: Robbins RA]]
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[[Category: Sandstrom, A.]]
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[[Category: Sandstrom A]]
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[[Category: Stroud, R M.]]
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[[Category: Stroud RM]]
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[[Category: Yeh, R.]]
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[[Category: Yeh R]]
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[[Category: Aquaporin]]
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[[Category: Brain edema]]
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[[Category: Center for structures of membrane protein]]
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[[Category: Csmp]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Phosphoprotein]]
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[[Category: Protein structure initiative]]
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[[Category: Proton exclusion]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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Current revision

Crystal Structure of Human Aquaporin 4 at 1.8 and its Mechanism of Conductance

PDB ID 3gd8

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