2zvy

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{{STRUCTURE_2zvy| PDB=2zvy | SCENE= }}
 
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===Structure of the periplasmic domain of MotB from Salmonella (crystal form II)===
 
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{{ABSTRACT_PUBMED_19627504}}
 
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==About this Structure==
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==Structure of the periplasmic domain of MotB from Salmonella (crystal form II)==
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[[2zvy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVY OCA].
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<StructureSection load='2zvy' size='340' side='right'caption='[[2zvy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2zvy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZVY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvy OCA], [https://pdbe.org/2zvy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zvy RCSB], [https://www.ebi.ac.uk/pdbsum/2zvy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MOTB_SALTY MOTB_SALTY] MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zvy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zvy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Torque generation in the Salmonella flagellar motor is coupled to translocation of H(+) ions through the proton-conducting channel of the Mot protein stator complex. The Mot complex is believed to be anchored to the peptidoglycan (PG) layer by the putative peptidoglycan-binding (PGB) domain of MotB. Proton translocation is activated only when the stator is installed into the motor. We report the crystal structure of a C-terminal periplasmic fragment of MotB (MotB(C)) that contains the PGB domain and includes the entire periplasmic region essential for motility. Structural and functional analyses indicate that the PGB domains must dimerize in order to form the proton-conducting channel. Drastic conformational changes in the N-terminal portion of MotB(C) are required both for PG binding and the proton channel activation.
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==See Also==
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Stator assembly and activation mechanism of the flagellar motor by the periplasmic region of MotB.,Kojima S, Imada K, Sakuma M, Sudo Y, Kojima C, Minamino T, Homma M, Namba K Mol Microbiol. 2009 Aug;73(4):710-8. Epub 2009 Jul 21. PMID:19627504<ref>PMID:19627504</ref>
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*[[Chemotaxis protein|Chemotaxis protein]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:019627504</ref><references group="xtra"/>
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</div>
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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<div class="pdbe-citations 2zvy" style="background-color:#fffaf0;"></div>
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[[Category: Homma, M.]]
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[[Category: Imada, K.]]
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==See Also==
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[[Category: Kojima, S.]]
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*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
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[[Category: Namba, K.]]
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== References ==
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[[Category: 2-layer sandwich]]
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<references/>
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[[Category: Bacterial flagellum]]
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__TOC__
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[[Category: Cell inner membrane]]
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</StructureSection>
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[[Category: Cell membrane]]
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[[Category: Large Structures]]
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[[Category: Chemotaxis]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Flagellar rotation]]
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[[Category: Homma M]]
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[[Category: Membrane]]
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[[Category: Imada K]]
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[[Category: Membrane protein]]
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[[Category: Kojima S]]
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[[Category: Transmembrane]]
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[[Category: Namba K]]

Current revision

Structure of the periplasmic domain of MotB from Salmonella (crystal form II)

PDB ID 2zvy

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