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1i4e
From Proteopedia
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| - | {{STRUCTURE_1i4e| PDB=1i4e | SCENE= }} | ||
| - | ===CRYSTAL STRUCTURE OF THE CASPASE-8/P35 COMPLEX=== | ||
| - | {{ABSTRACT_PUBMED_11260720}} | ||
| - | == | + | ==CRYSTAL STRUCTURE OF THE CASPASE-8/P35 COMPLEX== |
| - | [[1i4e]] is a 2 chain structure with sequence from [ | + | <StructureSection load='1i4e' size='340' side='right'caption='[[1i4e]], [[Resolution|resolution]] 3.00Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1i4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I4E FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4e OCA], [https://pdbe.org/1i4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i4e RCSB], [https://www.ebi.ac.uk/pdbsum/1i4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i4e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/P35_NPVAC P35_NPVAC] Functions as an inhibitor of the host RNA interference antiviral response. Inhibits the insect host cell apoptotic response initiated by the viral infection. Blocks as well the activity of members of the caspase family of proteases. Required for late and very late gene expression.<ref>PMID:16081248</ref> <ref>PMID:1962198</ref> <ref>PMID:26018163</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/1i4e_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i4e ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Caspase|Caspase]] | + | *[[Caspase 3D structures|Caspase 3D structures]] |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | < | + | </StructureSection> |
[[Category: Autographa californica nucleopolyhedrovirus]] | [[Category: Autographa californica nucleopolyhedrovirus]] | ||
| - | [[Category: Caspase-8]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Cirilli | + | [[Category: Large Structures]] |
| - | [[Category: Huang | + | [[Category: Cirilli M]] |
| - | [[Category: Myszka | + | [[Category: Huang Y]] |
| - | [[Category: Rich | + | [[Category: Myszka DG]] |
| - | [[Category: Wu | + | [[Category: Rich RL]] |
| - | [[Category: Xu | + | [[Category: Wu H]] |
| - | + | [[Category: Xu G]] | |
| - | + | ||
Current revision
CRYSTAL STRUCTURE OF THE CASPASE-8/P35 COMPLEX
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