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2vj2

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{{STRUCTURE_2vj2| PDB=2vj2 | SCENE= }}
 
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===HUMAN JAGGED-1, DOMAINS DSL AND EGFS1-3===
 
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{{ABSTRACT_PUBMED_18660822}}
 
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==About this Structure==
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==Human Jagged-1, domains DSL and EGFs1-3==
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[[2vj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ2 OCA].
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<StructureSection load='2vj2' size='340' side='right'caption='[[2vj2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vj2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJ2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cao|2cao]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj2 OCA], [https://pdbe.org/2vj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vj2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj2 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vj2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vj2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Notch receptor and its ligands are key components in a core metazoan signaling pathway that regulates the spatial patterning, timing and outcome of many cell-fate decisions. Ligands contain a disulfide-rich Delta/Serrate/LAG-2 (DSL) domain required for Notch trans-activation or cis-inhibition. Here we report the X-ray structure of a receptor binding region of a Notch ligand, the DSL-EGF3 domains of human Jagged-1 (J-1(DSL-EGF3)). The structure reveals a highly conserved face of the DSL domain, and we show, by functional analysis of Drosophila melanogster ligand mutants, that this surface is required for both cis- and trans-regulatory interactions with Notch. We also identify, using NMR, a surface of Notch-1 involved in J-1(DSL-EGF3) binding. Our data imply that cis- and trans-regulation may occur through the formation of structurally distinct complexes that, unexpectedly, involve the same surfaces on both ligand and receptor.
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==See Also==
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A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.,Cordle J, Johnson S, Tay JZ, Roversi P, Wilkin MB, de Madrid BH, Shimizu H, Jensen S, Whiteman P, Jin B, Redfield C, Baron M, Lea SM, Handford PA Nat Struct Mol Biol. 2008 Aug;15(8):849-57. Epub 2008 Jul 27. PMID:18660822<ref>PMID:18660822</ref>
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*[[Journal:JBSD:12|Journal:JBSD:12]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:018660822</ref><ref group="xtra">DOI 10.1080/07391102.2012.674184</ref><references group="xtra"/>
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 2vj2" style="background-color:#fffaf0;"></div>
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[[Category: Cordle, J.]]
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== References ==
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[[Category: Handford, P A.]]
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<references/>
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[[Category: Johnson, S.]]
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__TOC__
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[[Category: Lea, S M.]]
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</StructureSection>
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[[Category: Roversi, P.]]
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[[Category: Human]]
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[[Category: Tay, J Z.]]
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[[Category: Large Structures]]
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[[Category: Cordle, J]]
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[[Category: Handford, P A]]
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[[Category: Johnson, S]]
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[[Category: Lea, S M]]
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[[Category: Roversi, P]]
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[[Category: Tay, J Z]]
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[[Category: Calcium]]
[[Category: Developmental protein]]
[[Category: Developmental protein]]
[[Category: Disease mutation]]
[[Category: Disease mutation]]
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[[Category: Notch]]
[[Category: Notch]]
[[Category: Notch signaling pathway]]
[[Category: Notch signaling pathway]]
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[[Category: Polymorphism]]
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[[Category: Protein binding]]
[[Category: Protein-binding]]
[[Category: Protein-binding]]
[[Category: Signalling]]
[[Category: Signalling]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]

Current revision

Human Jagged-1, domains DSL and EGFs1-3

PDB ID 2vj2

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