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2bel

From Proteopedia

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[[Image:2bel.gif|left|200px]]<br /><applet load="2bel" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2bel, resolution 2.11&Aring;" />
 
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'''STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE'''<br />
 
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==Disease==
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==Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone==
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Known diseases associated with this structure: Cortisone reductase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600713 600713]]
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<StructureSection load='2bel' size='340' side='right'caption='[[2bel]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BEL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [https://pdbe.org/2bel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [https://www.ebi.ac.uk/pdbsum/2bel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bel ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[https://omim.org/entry/604931 604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
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== Function ==
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[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/2bel_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bel ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2BEL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=NAP:'>NAP</scene> and <scene name='pdbligand=CBO:'>CBO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] Known structural/functional Site: <scene name='pdbsite=AC1:Cl+Binding+Site+For+Chain+C'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA].
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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[[Category: 11-beta-hydroxysteroid dehydrogenase]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Abrahmsen, L.]]
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[[Category: Abrahmsen L]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bray, J.]]
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[[Category: Bray J]]
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[[Category: Debreczeni, J E.]]
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[[Category: Debreczeni JE]]
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[[Category: Delft, F Von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elleby B]]
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[[Category: Elleby, B.]]
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[[Category: Kavanagh K]]
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[[Category: Kavanagh, K.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Sharma S]]
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[[Category: Sharma, S.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Svensson S]]
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[[Category: Svensson, S.]]
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[[Category: Wu X]]
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[[Category: Wu, X.]]
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[[Category: Von Delft F]]
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[[Category: CBO]]
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[[Category: CL]]
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[[Category: NAP]]
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[[Category: drug target]]
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[[Category: glucocorticoid activation]]
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[[Category: hormone metabolism]]
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[[Category: inhibitor]]
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[[Category: microsome]]
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[[Category: nadp]]
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[[Category: oxidoreductase]]
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[[Category: short-chain dehydrogenase/reductase]]
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[[Category: steroid metabolism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:37:00 2008''
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Current revision

Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone

PDB ID 2bel

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