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1n6u

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{{STRUCTURE_1n6u| PDB=1n6u | SCENE= }}
 
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===NMR structure of the interferon-binding ectodomain of the human interferon receptor===
 
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{{ABSTRACT_PUBMED_12842042}}
 
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==About this Structure==
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==NMR structure of the interferon-binding ectodomain of the human interferon receptor==
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[[1n6u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6U OCA].
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<StructureSection load='1n6u' size='340' side='right'caption='[[1n6u]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n6u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N6U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n6u OCA], [https://pdbe.org/1n6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n6u RCSB], [https://www.ebi.ac.uk/pdbsum/1n6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n6u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INAR2_HUMAN INAR2_HUMAN] Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.<ref>PMID:8181059</ref> <ref>PMID:7665574</ref> <ref>PMID:7759950</ref> <ref>PMID:11682488</ref> <ref>PMID:12105218</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/1n6u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n6u ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Journal:Cell:1|Journal:Cell:1]]
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*[[Interferon|Interferon]]
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*[[Interferon receptor 3D structures|Interferon receptor 3D structures]]
*[[Multiple sclerosis|Multiple sclerosis]]
*[[Multiple sclerosis|Multiple sclerosis]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012842042</ref><ref group="xtra">DOI 10.1016/j.cell.2011.06.048</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Anglister, J.]]
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[[Category: Large Structures]]
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[[Category: Chill, J H.]]
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[[Category: Anglister J]]
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[[Category: Levy, R.]]
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[[Category: Chill JH]]
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[[Category: Quadt, S R.]]
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[[Category: Levy R]]
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[[Category: Schreiber, G.]]
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[[Category: Quadt SR]]
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[[Category: Fibronectin fold]]
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[[Category: Schreiber G]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin fold]]
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[[Category: Two-domain structure]]
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Current revision

NMR structure of the interferon-binding ectodomain of the human interferon receptor

PDB ID 1n6u

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