1tqn

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{{STRUCTURE_1tqn| PDB=1tqn | SCENE= }}
 
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===Crystal Structure of Human Microsomal P450 3A4===
 
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{{ABSTRACT_PUBMED_15258162}}
 
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==About this Structure==
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==Crystal Structure of Human Microsomal P450 3A4==
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[[1tqn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQN OCA].
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<StructureSection load='1tqn' size='340' side='right'caption='[[1tqn]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqn OCA], [https://pdbe.org/1tqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tqn RCSB], [https://www.ebi.ac.uk/pdbsum/1tqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tqn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tqn ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cytochrome P450|Cytochrome P450]]
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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*[[Drug Metabolism by CYP450 Enzymes|Drug Metabolism by CYP450 Enzymes]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015258162</ref><ref group="xtra">PMID:016086027</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Large Structures]]
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[[Category: Griffin, K J.]]
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[[Category: Griffin KJ]]
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[[Category: Johnson, E F.]]
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[[Category: Johnson EF]]
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[[Category: Schoch, G A.]]
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[[Category: Schoch GA]]
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[[Category: Stout, C D.]]
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[[Category: Stout CD]]
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[[Category: Wester, M R.]]
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[[Category: Wester MR]]
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[[Category: Yano, J K.]]
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[[Category: Yano JK]]
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[[Category: Cyp3a4]]
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[[Category: Drug metabolizing enzyme]]
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[[Category: Heme]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: P450]]
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Current revision

Crystal Structure of Human Microsomal P450 3A4

PDB ID 1tqn

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