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1yln
From Proteopedia
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| - | {{STRUCTURE_1yln| PDB=1yln | SCENE= }} | ||
| - | ===The Crystal Structure of the Protein of Unknown Function VCA0042 from Vibrio cholerae O1=== | ||
| - | == | + | ==The Crystal Structure of the Protein of Unknown Function VCA0042 from Vibrio cholerae O1== |
| - | [[1yln]] is a 1 chain structure with sequence from [ | + | <StructureSection load='1yln' size='340' side='right'caption='[[1yln]], [[Resolution|resolution]] 2.20Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[1yln]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1 Vibrio cholerae O1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YLN FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OSE:O-SULFO-L-SERINE'>OSE</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yln OCA], [https://pdbe.org/1yln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yln RCSB], [https://www.ebi.ac.uk/pdbsum/1yln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yln ProSAT], [https://www.topsan.org/Proteins/MCSG/1yln TOPSAN]</span></td></tr> |
| - | [[ | + | </table> |
| - | [ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/YCGRL_VIBCH YCGRL_VIBCH] May act as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Increasing levels of c-di-GMP lead to decreased motility (Potential). Binds bis-(3'-5') cyclic diguanylic acid (c-di-GMP) with a dissociation constant of 170 nM in the presence of 10 mM KCl and with 100 nM in its absence. Binds 1 to 2 c-di-GMP per subunit. Only 1 c-di-GMP is seen in the wild-type crystal, while 2 are seen in the mutant. Depending on the concentration of K(+) stoichiometries of 1:1, 1.43:1 and 2:1 are determined by isothermal titration calorimetry. |
| - | [ | + | == Evolutionary Conservation == |
| - | [[ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [ | + | Check<jmol> |
| - | [[ | + | <jmolCheckbox> |
| - | [[Category: | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yl/1yln_consurf.spt"</scriptWhenChecked> |
| - | [[Category: | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[Category: | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[Category: | + | </jmolCheckbox> |
| - | [[Category: | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yln ConSurf]. |
| - | [[Category: | + | <div style="clear:both"></div> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vibrio cholerae O1]] | ||
| + | [[Category: Collart F]] | ||
| + | [[Category: Joachimiak A]] | ||
| + | [[Category: Moy S]] | ||
| + | [[Category: Zhang R]] | ||
| + | [[Category: Zhou M]] | ||
Current revision
The Crystal Structure of the Protein of Unknown Function VCA0042 from Vibrio cholerae O1
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