3ger

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{{STRUCTURE_3ger| PDB=3ger | SCENE= }}
 
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===Guanine riboswitch bound to 6-chloroguanine===
 
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{{ABSTRACT_PUBMED_19523903}}
 
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==About this Structure==
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==Guanine riboswitch bound to 6-chloroguanine==
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[[3ger]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GER OCA].
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<StructureSection load='3ger' size='340' side='right'caption='[[3ger]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ger]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GER FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6GU:6-CHLOROGUANINE'>6GU</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ger FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ger OCA], [https://pdbe.org/3ger PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ger RCSB], [https://www.ebi.ac.uk/pdbsum/3ger PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ger ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Purine riboswitches discriminate between guanine and adenine by at least 10,000-fold based on the identity of a single pyrimidine (Y74) that forms a Watson-Crick base pair with the ligand. To understand how this high degree of specificity for closely related compounds is achieved through simple pairing, we investigated their interaction with purine analogs with varying functional groups at the 2- and 6-positions that have the potential to alter interactions with Y74. Using a combination of crystallographic and calorimetric approaches, we find that binding these purines is often facilitated by either small structural changes in the RNA or tautomeric changes in the ligand. This work also reveals that, along with base pairing, conformational restriction of Y74 significantly contributes to nucleobase selectivity. These results reveal that compounds that exploit the inherent local flexibility within riboswitch binding pockets can alter their ligand specificity.
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==See Also==
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Adaptive ligand binding by the purine riboswitch in the recognition of guanine and adenine analogs.,Gilbert SD, Reyes FE, Edwards AL, Batey RT Structure. 2009 Jun 10;17(6):857-68. PMID:19523903<ref>PMID:19523903</ref>
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*[[Riboswitch|Riboswitch]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:019523903</ref><references group="xtra"/>
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</div>
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[[Category: Batey, R T.]]
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<div class="pdbe-citations 3ger" style="background-color:#fffaf0;"></div>
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[[Category: Gilbert, S D.]]
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[[Category: Base triple]]
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==See Also==
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[[Category: Double helix]]
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*[[Riboswitch 3D structures|Riboswitch 3D structures]]
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[[Category: Guanine]]
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== References ==
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[[Category: Mrna]]
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<references/>
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[[Category: Riboswitch]]
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__TOC__
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[[Category: Rna]]
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</StructureSection>
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[[Category: Rna-ligand complex]]
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[[Category: Bacillus subtilis]]
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[[Category: Three-way junction]]
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[[Category: Large Structures]]
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[[Category: Batey RT]]
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[[Category: Gilbert SD]]

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Guanine riboswitch bound to 6-chloroguanine

PDB ID 3ger

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