1nwy

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{{STRUCTURE_1nwy| PDB=1nwy | SCENE= }}
 
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===COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH AZITHROMYCIN===
 
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{{ABSTRACT_PUBMED_12623020}}
 
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==About this Structure==
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==COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH AZITHROMYCIN==
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[[1nwy]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWY OCA].
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<StructureSection load='1nwy' size='340' side='right'caption='[[1nwy]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nwy]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NWY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZIT:AZITHROMYCIN'>ZIT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwy OCA], [https://pdbe.org/1nwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nwy RCSB], [https://www.ebi.ac.uk/pdbsum/1nwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL23_DEIRA RL23_DEIRA] One of the early assembly protein (By similarity) it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Forms the main docking site for trigger factor binding to the ribosome (PubMed:16091460 and PubMed:16271892).[HAMAP-Rule:MF_01369]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nwy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of erythromycin, exhibit elevated activity against a number of penicillin- and macrolide-resistant pathogenic bacteria. Analysis of the crystal structures of the large ribosomal subunit from Deinococcus radiodurans complexed with azithromycin or ABT-773 indicates that, despite differences in the number and nature of their contacts with the ribosome, both compounds exert their antimicrobial activity by blocking the protein exit tunnel. In contrast to all macrolides studied so far, two molecules of azithromycin bind simultaneously to the tunnel. The additional molecule also interacts with two proteins, L4 and L22, implicated in macrolide resistance. These studies illuminated and rationalized the enhanced activity of the drugs against specific macrolide-resistant bacteria.
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==See Also==
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Structural basis for the antibiotic activity of ketolides and azalides.,Schlunzen F, Harms JM, Franceschi F, Hansen HA, Bartels H, Zarivach R, Yonath A Structure. 2003 Mar;11(3):329-38. PMID:12623020<ref>PMID:12623020</ref>
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*[[Ribosomal protein L11|Ribosomal protein L11]]
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*[[Ribosomal protein L13|Ribosomal protein L13]]
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*[[Ribosomal protein L14|Ribosomal protein L14]]
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*[[Ribosomal protein L15|Ribosomal protein L15]]
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*[[Ribosomal protein L16|Ribosomal protein L16]]
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*[[Ribosomal protein L17|Ribosomal protein L17]]
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*[[Ribosomal protein L18|Ribosomal protein L18]]
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*[[Ribosomal protein L19|Ribosomal protein L19]]
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*[[Ribosomal protein L2|Ribosomal protein L2]]
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*[[Ribosomal protein L20|Ribosomal protein L20]]
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*[[Ribosomal protein L21|Ribosomal protein L21]]
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*[[Ribosomal protein L22|Ribosomal protein L22]]
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*[[Ribosomal protein L23|Ribosomal protein L23]]
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*[[Ribosomal protein L24|Ribosomal protein L24]]
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*[[Ribosomal protein L27|Ribosomal protein L27]]
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*[[Ribosomal protein L29|Ribosomal protein L29]]
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*[[Ribosomal protein L3|Ribosomal protein L3]]
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*[[Ribosomal protein L30|Ribosomal protein L30]]
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*[[Ribosomal protein L31|Ribosomal protein L31]]
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*[[Ribosomal protein L32|Ribosomal protein L32]]
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*[[Ribosomal protein L33|Ribosomal protein L33]]
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*[[Ribosomal protein L34|Ribosomal protein L34]]
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*[[Ribosomal protein L35|Ribosomal protein L35]]
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*[[Ribosomal protein L36|Ribosomal protein L36]]
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*[[Ribosomal protein L4|Ribosomal protein L4]]
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*[[Ribosomal protein L5|Ribosomal protein L5]]
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*[[Ribosomal protein L6|Ribosomal protein L6]]
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*[[Ribosomal protein L9|Ribosomal protein L9]]
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*[[User:Wayne Decatur/Haloarcula Large Ribosomal Subunit With Azithromycin|User:Wayne Decatur/Haloarcula Large Ribosomal Subunit With Azithromycin]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:012623020</ref><references group="xtra"/>
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</div>
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<div class="pdbe-citations 1nwy" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Bartels, H.]]
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[[Category: Large Structures]]
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[[Category: Franceschi, F.]]
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[[Category: Bartels H]]
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[[Category: Hansen, H A.S.]]
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[[Category: Franceschi F]]
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[[Category: Harms, J.]]
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[[Category: Hansen HAS]]
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[[Category: Schluenzen, F.]]
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[[Category: Harms J]]
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[[Category: Yonath, A.]]
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[[Category: Schluenzen F]]
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[[Category: Zarivach, R.]]
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[[Category: Yonath A]]
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[[Category: 50]]
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[[Category: Zarivach R]]
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[[Category: Azithromycin]]
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[[Category: Ketolide]]
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[[Category: Macrolide]]
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[[Category: Ribosomal]]
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[[Category: Ribosome]]
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Current revision

COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH AZITHROMYCIN

PDB ID 1nwy

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