3inb
From Proteopedia
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| - | {{STRUCTURE_3inb| PDB=3inb | SCENE= }} | ||
| - | ===Structure of the measles virus hemagglutinin bound to the CD46 receptor=== | ||
| - | {{ABSTRACT_PUBMED_20010840}} | ||
| - | == | + | ==Structure of the measles virus hemagglutinin bound to the CD46 receptor== |
| - | [[3inb]] is a 4 chain structure with sequence from [ | + | <StructureSection load='3inb' size='340' side='right'caption='[[3inb]], [[Resolution|resolution]] 3.10Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3inb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Measles_virus_strain_Edmonston Measles virus strain Edmonston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3inb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inb OCA], [https://pdbe.org/3inb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3inb RCSB], [https://www.ebi.ac.uk/pdbsum/3inb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3inb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HEMA_MEASE HEMA_MEASE] Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.<ref>PMID:9811778</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/3inb_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3inb ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The highly contagious measles virus infects millions of individuals worldwide, causing serious disease in children of developing countries. Infection is initiated by attachment of the measles virus hemagglutinin (MV-H), a glycoprotein anchored to the virus envelope, to the host cell receptors CD46 or signaling lymphocyte activation molecule (SLAM). Here we report the crystal structure of MV-H in complex with a CD46 protein spanning the two N-terminal domains. A unique groove at the side of the MV-H beta-propeller domain, which is absent in homologous paramyxovirus attachment proteins, engages residues in both CD46 domains. Key contacts involve a protruding loop in the N-terminal CD46 domain that carries two sequential proline residues (PP motif) and penetrates deeply into a hydrophobic socket in MV-H. We identify a similar PP motif in SLAM, defining a common measles virus recognition epitope in the CD46 and SLAM receptor proteins. | ||
| - | + | Structure of the measles virus hemagglutinin bound to the CD46 receptor.,Santiago C, Celma ML, Stehle T, Casasnovas JM Nat Struct Mol Biol. 2010 Jan;17(1):124-9. Epub 2009 Dec 13. PMID:20010840<ref>PMID:20010840</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | < | + | </div> |
| + | <div class="pdbe-citations 3inb" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Measles virus strain | + | [[Category: Large Structures]] |
| - | [[Category: Casasnovas | + | [[Category: Measles virus strain Edmonston]] |
| - | [[Category: Celma | + | [[Category: Casasnovas JM]] |
| - | [[Category: Santiago | + | [[Category: Celma ML]] |
| - | [[Category: Stehle | + | [[Category: Santiago C]] |
| - | + | [[Category: Stehle T]] | |
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Current revision
Structure of the measles virus hemagglutinin bound to the CD46 receptor
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