1i3o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:20, 9 August 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_1i3o| PDB=1i3o | SCENE= }}
 
-
===CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3===
 
-
{{ABSTRACT_PUBMED_11257232}}
 
-
==About this Structure==
+
==CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3==
-
[[1i3o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I3O OCA].
+
<StructureSection load='1i3o' size='340' side='right'caption='[[1i3o]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1i3o]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I3O FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i3o OCA], [https://pdbe.org/1i3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i3o RCSB], [https://www.ebi.ac.uk/pdbsum/1i3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i3o ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/1i3o_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i3o ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The molecular mechanism(s) that regulate apoptosis by caspase inhibition remain poorly understood. The main endogenous inhibitors are members of the IAP family and are exemplified by XIAP, which regulates the initiator caspase-9, and the executioner caspases-3 and -7. We report the crystal structure of the second BIR domain of XIAP (BIR2) in complex with caspase-3, at a resolution of 2.7 A, revealing the structural basis for inhibition. The inhibitor makes limited contacts through its BIR domain to the surface of the enzyme, and most contacts to caspase-3 originate from the N-terminal extension. This lies across the substrate binding cleft, but in reverse orientation compared to substrate binding. The mechanism of inhibition is due to a steric blockade prohibitive of substrate binding, and is distinct from the mechanism utilized by synthetic substrate analog inhibitors.
-
==See Also==
+
Structural basis for the inhibition of caspase-3 by XIAP.,Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS Cell. 2001 Mar 9;104(5):791-800. PMID:11257232<ref>PMID:11257232</ref>
-
*[[Caspase|Caspase]]
+
-
*[[Caspase-3 Regulatory Mechanisms|Caspase-3 Regulatory Mechanisms]]
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:011257232</ref><references group="xtra"/>
+
</div>
 +
<div class="pdbe-citations 1i3o" style="background-color:#fffaf0;"></div>
 +
 
 +
==See Also==
 +
*[[Caspase 3D structures|Caspase 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Fesik, S W.]]
+
[[Category: Large Structures]]
-
[[Category: Liddington, R C.]]
+
[[Category: Fesik SW]]
-
[[Category: Renatus, M.]]
+
[[Category: Liddington RC]]
-
[[Category: Riedl, S J.]]
+
[[Category: Renatus M]]
-
[[Category: Salvesen, G S.]]
+
[[Category: Riedl SJ]]
-
[[Category: Schwarzenbacher, R.]]
+
[[Category: Salvesen GS]]
-
[[Category: Sun, C.]]
+
[[Category: Schwarzenbacher R]]
-
[[Category: Zhou, Q.]]
+
[[Category: Sun C]]
-
[[Category: Apoptosis]]
+
[[Category: Zhou Q]]
-
[[Category: Caspase]]
+
-
[[Category: Complex]]
+
-
[[Category: Iap]]
+

Current revision

CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3

PDB ID 1i3o

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i3o"
Personal tools